Mirgraine

Background: The 5-hydroxytryptamine 1B/1D agonists, or triptans, is the newest class of drugs to generate operable for the acute treatment of migraine as per Solomon. This class shortly includes sumatriptan, zolmitriptan, naratriptan, and rizatriptan. The efficacy of rizatriptan in this acute treatment of migraine has been establish against placebo and other oral triptans in controlled comparative trials. Objective: The US Migraine Assessment Protocol (USMAP) collected data on the use of rizatriptan in a naturalistic setting reflecting clinical practice. This paper presents results for patients enrolled in the USMAP study who had never taken a triptan before the study. Methods: At enrollment, 216 patients completed a questionnaire describing their responses to their current nontriptan medications. They were wherefore given specially packaged samples of 4 standard 10-mg rizatriptan tablets and 4 orally disintegrating 10-mg rizatriptan tablets (wafers) and were asked to take a different formulation for separately of their next 2 attacks, the sequence to be at their discretion. inwardly ?24 hours after victorious rizatriptan, patients were to call a toll-free number to report their responses to rizatriptan using an interactive voice-response system.

Results: Within 2 hours after initial dosing of rizatriptan, significantly more patients taking both the rizatriptan tablet or the rizatriptan wafer reported onset of pain relief, had become largely symptom free, and were able to resume usual activities compared with their service line responses to nontriptans (P < 0.05). In addition, compared with their baseline responses to nontriptans, significantly more patients taking all rizatriptan formulation had mild or no pain 2 hours after dosing (P < 0.05). More than twice as many patients taking the rizatriptan tablets or wafers were either somewhat or very cheery with the medication compared with their satisfaction with nontriptans (P < 0.05). Conclusions: In the... If you want to get a full essay, order it on our website: Orderessay

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