function of RB protein

PROJECT
Function of Rb Protein





INTRODUCTION

The retinoblastoma divisor (RB) is located on chromose 13 at position q14. It has 27 exons and is more than 200kilobases. Its mRNA codes for 928- aminic-acid-long polypeptide. Since it is convey in each(prenominal) cells, it is called a household gene. The product of this gene is the retinoblastoma protein, which is actually a tumor suppressor protein. (6) Retinoblastoma protein, pRB, is a isobilateral heterodimer and it cannot function unless the dimers are not together. So, the mutations that occur in the amino acids that integrate these dimers alter the protein function. (7)
E2F is a gene family which is collectively cognize as transcription factors. There are many members of this family and all of them are involved in cell cycle regulation, via ordinance a number of genes important in cell proliferation, and deoxyribonucleic acid synthesis. Their major role in cell cycle is providing the vicissitude from G1 to S-phase. (1,3-5,8,10,11)
There are eight members of this family; E2F1-6 and DP1-2. They can function as transcriptional activators or repressors. Multiple E2Fs can bind to a cross gene asynchronously. (1,8,10) The expression of these members differ during cell proliferation response. Expression take aim of E2F1 increases at G1-S boundary.



E2F3 and E2F5 levels increases in early G1 and does nor change dramatically afterward that. E2F4 is expressed constitutively.
Several E2F genes are shown to function as oncogenes in cancer development. (1) For example, E2F1, a member of E2F family, acts both as an oncogen and a tumor suppressor gene. It plays a dual role, on the star hand by inducing S-promoting genes transcription and on the another(prenominal) by directly influencing apoptosis execution. (2,9)
A popular warning for how E2F family members regulate G1/S-phase-specific gene expression invokes a complex variety of protein-protein and protein-DNA interactions that change as cells progress through the cell cycle. (10)
Since E2F bottom genes show...If you want to get a full essay, order it on our website: Orderessay



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