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Quantitative Determination of Ferrous sulphate Heptahydrate Tablet disintegration Profiles

By Judson Lowie Ramos

This method describes the quantitation of Ferrous Sulfate Heptahydrate Tablet dissipation Profiles utilize UV-vis Spectrophotometry. The method involves complexation of Fe2+ ion with 1,10-Phenanthroline (a bidentate ligand) which develops a red to imperial color solution. This allows the quantification of Fe2+ in the wavelength region 490nm to 580nm. The methodology is limited to role of trace amounts of Fe2+ ion, being 6.0ppm a maximum limit of the part. Nevertheless, the procedure can be modified base on the trade good of the sample. The procedure below is intended solely for detecting minute of arc quantity of Fe2+, which could be manifested by the dissolution of Ferrous Sulfate tablet because of its slow disintegration character.
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Preparation of 1, 10-Phenanthroline: Dissolve 200mg of 1, 10-Phenanhtroline monohydrate in 160mL deionized water at 80?C. Dilute to 200mL.
Preparation of acetate Buffer Solution: Dissolve 25.6g of ammonium acetate in 100mL water. Add 24mL of glacial acetic acid and dilute to 200mL using deionized water.
Preparation of timeworn Solution
Dissolve 497.9mg of FeSO4 ? 7H2O in 50mL deionized water.



Once completely dissolve, dilute the solution with deionized water to 100mL volumetric flask. Pipette 10mL impute and volume to 100mL using deionized water. Label this solution as measuring stick Stock Solution.
Preparation of 0.1ppm and 0.5ppm Standard Solution
From the Standard Stock Solution, pipet 10mL portion and dilute to 100mL volumetric flask with deionized water. Pippete 1mL and 5mL portions; and treat with 10mL archetype solution and 10mL 1, 10-Phenanthroline solution. Dilute to 100mL using 0.1N HCl. Label the solution as Standard 1 and Standard 2 respectively.
Preparation of 1.0ppm, 2.0ppm, 3.5ppm and 6.0ppm Standard Solution
From the Standard Stock Solution, pipette...If you want to get a unspoiled essay, order it on our website: Orderessay



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