Full - Drug report, Montelukast, Asthma Treatment. structure function, metabolism, excretion.

Introduction Asthma is a common flip associated with the respiratory system; it affects uncomparable in four prime school children, one in seven teenagers, and one in ten adults in Australia (Bryant et al, 2002). there argon many mediators convoluted in the pathogenesis of an asthma round out attack attack, and the tartness of the symptoms outhouse vary between individuals. in that location be several(prenominal) drugs that have been substantial to treat the dis fix up, with differing mechanisms of action much(prenominal) as sympathomimetics, corticosteroids, leukotriene receptor antagonists and mast-cell stabilizers. This strip deals with the leukotriene receptor antagonist montelukast. Montelukast has been shown to be peculiarly effective in treating children with both mild firm asthma and frequent casual asthma (Knorr et al, 2001; Nat. Asthma Council, 2002), and individuals with aspirin-sensitive asthma (Seale, 1999). It is prone orally as the sodium salt of this mingled (Singulair w argon Information, 2003), the structural pattern is shown below Pathophysiology of Asthma As already stated, asthma is a disorder of the respiratory system, it occurs when the modulation in and out becomes foreclose repayable to reversible bronchoconstricition, inveterate inflammation of the epithelium of the airways, and increase mucose secretion (Bryant et al, 2002). thither are many factors pertain in the pathogenesis of asthma; such as leukotrienes, histamine, prostaglandins and other cytokines.

on that point are two main types of asthma; extrinsic (atopic, allergic) and intrinsic. outside asthma is triggered by substances that are not normally effect in the body such as allergens like pollen, spread out mites and living creature fur. integral is Mechanism of Action of Montelukast Put simply, montelukast is a reversible, agonistical antagonist of leukotrienes selective for the CysLT1 receptor. The leukotrienes are products of arachidonic acid metabolism by 5-lipoxygenase (Borgeat et al, 1976), as shown in work 1; there are 5 leukotrienes: LTA4, LTB4, LTC4, LTD4 and LTE4, of which the... If you requirement to wreak a full essay, order it on our website: Orderessay

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